Polysaccharide Based Self-Driven Tubular Micro/Nanomotors as a Comprehensive Platform for Quercetin Loading and Anti-inflammatory Function

• Published in: Biomacromolecules
• Main Authors: Yan, Zhiyu, Ding, Ni, Lin, Songyi, Zhang, Siqi, Xiao, Yingchen, Xie, Yuxin, Zhang, Simin
• Format: Journal Article
• Language: English
• Published: United States 24.09.2024
• ISSN: 1525-7797; 1526-4602; 1526-4602
• DOI: 10.1021/acs.biomac.4c01084

Quercetin (QR) is a natural flavonoid with strong anti-inflammatory properties, but it suffers from poor water solubility and bioavailability. Micro/nanomotors (NMs) are tiny devices that convert external energy or chemical fuels into an autonomous motion. They are characterized by their small size, rapid movement, and self-assembly capabilities, which can enhance the delivery of bioactive ingredients. The study synthesized natural polysaccharide-based nanotubes (NTs) using a layer-by-layer self-assembly method and combined with urease (Ure), glucose oxidase (GOx), and Fe O to create three types of NMs. These NMs were well-dispersed and biocompatible. In vitro experiments showed that NMs-Fe O has excellent photothermal conversion properties and potential for use in photothermal therapy. Cellular inflammation model results demonstrated that QR-loaded NMs were not only structurally stable but also improved bioavailability and effectively inhibited the release of inflammatory mediators such as IL-1β and IL-6, providing a safe and advanced carrier system for the effective use of bioactive components in food.