Abstract P259: Smoking Increases Risks of Death and Stroke in Both Men and Women. Absolute Risk Difference of Stroke is Likely to be Larger in Women

• Published in: Circulation (New York, N.Y.) Vol. 135; no. suppl_1
• Main Authors: Ohsawa, Masaki, Ogasawara, Kuniaki, Omama, Shinichi, Tanno, Kozo, Itai, Kazuyoshi, Yonekura, Yuki, Nakamura, Motoyuki, Ishibashi, Yasuhiro, Kuribayashi, Toru, Onoda, Toshiyuki, Sakata, Kiyomi, Tanaka, Fumitaka, Ohta, Mutsuko, Seki, Hirobumi, Konishi, Kazuki, Okayama, Akira
• Format: Journal Article
• Language: English
• Published: 07.03.2017
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.135.suppl_1.p259

Abstract only Background: Smoking is an important risk factor for cardiovascular disease, however, to what extent smoking increases excessive deaths and strokes in a general population has not been sufficiently examined especially in women. Methods: A total of 10,382 female and male participants aged 65 years or older were divided into two groups according to smoking status (current smoker; never smoker). Past smokers were excluded. Main outcomes were all-cause death and incident stroke. Age-adjusted mortality and incidence rates were estimated in the groups using Poisson’s regression analysis. Age-adjusted rate ratios (RR) and excess events (EE per 1000 person-years) attributable to smoking were determined using the rate in never smokers as a reference. Results: There were 1410 deaths and 735 strokes during the 9.0-year observation period (90,099 person-years). Smoking contributed to a 2.3-fold higher risk of death in women and 1.8-fold higher risk in men. It contributed to 12 excess deaths per 1000 person-years in both men and women. The rate ratio and excessive events of stroke were likely to be higher in women than those in men (RR: 2.6 vs. 1.6; EE: 9.3 vs 5.0, see table). Conclusion: Smoking significantly increases risks of death and stroke not only in men but also in women. Absolute risk difference of stroke attributable to smoking is likely to be larger in women than in men.