Solubility Enhancement of Clozapine by Co-crystals

Cocrystallization of drug with coformers is a promising approach to alter the solid state properties of drug substances like solubility and dissolution. The objective of the present work was preparation, formulation and evaluation of the clozapine cocrystal by screening various coformers. Clozapine...

Full description

Saved in:
Bibliographic Details
Published inInternational Journal For Multidisciplinary Research Vol. 5; no. 3
Main Authors -, Prachi Gohil, -, Hitesh Jain, -, Satyajit Sahoo, -, D. B. Meshram
Format Journal Article
LanguageEnglish
Published 22.05.2023
Online AccessGet full text

Cover

More Information
Summary:Cocrystallization of drug with coformers is a promising approach to alter the solid state properties of drug substances like solubility and dissolution. The objective of the present work was preparation, formulation and evaluation of the clozapine cocrystal by screening various coformers. Clozapine co-crystals were prepared using different coformers like benzoic acid, fumaric acid, sodium saccharin and sodium acetate. Cocrystals were prepared using solvent evaporation method and solvent drop grinding method. The prepared co-crystals were evaluated for saturation solubility, drug content, dissolution studies, XRD studies and DSC analysis.
ISSN:2582-2160
2582-2160
DOI:10.36948/ijfmr.2023.v05i03.3158