Usefulness of the C 2 HEST score to predict new onset atrial fibrillation. A systematic review and meta‐analysis on >11 million subjects

• Published in: European journal of clinical investigation Vol. 54; no. 11; p. e14293
• Main Authors: Pastori, Daniele, Menichelli, Danilo, Li, Yan‐Guang, Brogi, Tommaso, Biccirè, Flavio Giuseppe, Pignatelli, Pasquale, Farcomeni, Alessio, Lip, Gregory Y. H.
• Format: Journal Article
• Language: English
• Published: England 01.11.2024
• Subjects: Aged; Area Under Curve; Atrial Fibrillation - epidemiology; Cardiovascular Diseases - epidemiology; Female; Humans; Male; Middle Aged; Observational Studies as Topic; Risk Assessment - methods; atrial fibrillation; prevention; risk stratification; C2HEST score
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/eci.14293

The incidence of new-onset atrial fibrillation (NOAF) is increasing in the last decades. NOAF is associated with worse long-term prognosis. The C HEST score has been recently proposed to stratify the risk of NOAF. Pooled data on the performance of the C HEST score are lacking. Systematic review and meta-analysis of observational studies reporting data on NOAF according to the C HEST score. We searched PubMed, Web of Science and Google scholar databases without time restrictions until June 2023 according to PRISMA guidelines. Meta-analysis of the area under the curve (AUC) with 95% confidence interval (95% CI) and a sensitivity analysis according to setting of care and countries were performed. Of 360 studies, 17 were included in the analysis accounting for 11,067,496 subjects/patients with 307,869 NOAF cases. Mean age ranged from 41.3 to 71.2 years. The prevalence of women ranged from 10.6 to 54.75%. The pooled analysis gave an AUC of .70 (95% CI .66-.74). A subgroup analysis on studies from general population/primary care yielded an AUC of 0.69 (95% CI 0.64-0.75). In the subgroup of patients with cardiovascular disease, the AUC was .71 (.69-.79). The C HEST score performed similarly in Asian (AUC .72, 95% CI .68-.77), and in Western patients (AUC .68, 95% CI .62-.75). The best performance was observed in studies with a mean age <50 years (n = 3,144,704 with 25,538 NOAF, AUC .78, 95% CI .76-.79). The C HEST score may be used to predict NOAF in primary and secondary prevention patients, and in patients across different countries. Early detection of NOAF may aid prompt initiation of management and follow-up, potentially leading to a reduction of AF-related complications.