Clinical application of oral contrast-enhanced ultrasound in evaluating the preoperative T staging of gastric cancer
BACKGROUND Oral contrast-enhanced ultrasound (OCEUS) is widely used in the noninvasive diagnosis and screening of gastric cancer (GC) in China. AIM To investigate the clinical application of OCEUS in evaluating the preoperative T staging of gastric cancer. METHODS OCEUS was performed before the oper...
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| Published in | World journal of gastroenterology : WJG Vol. 30; no. 41; pp. 4439 - 4448 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Baishideng Publishing Group Inc
07.11.2024
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| Subjects | |
| Online Access | Get full text |
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| Summary: | BACKGROUND Oral contrast-enhanced ultrasound (OCEUS) is widely used in the noninvasive diagnosis and screening of gastric cancer (GC) in China. AIM To investigate the clinical application of OCEUS in evaluating the preoperative T staging of gastric cancer. METHODS OCEUS was performed before the operation, and standard ultrasound images were retained. The depth of infiltration of GC (T-stage) was evaluated according to the American Joint Committee on Cancer 8th edition of the tumor-node-metastasis staging criteria. Finally, with postoperative pathological staging as the gold standard reference, the sensitivity, specificity, negative predictive value, positive predictive value, and diagnostic value of OCEUS T staging were evaluated. RESULTS OCEUS achieved diagnostic accuracy rates of 76.6% (T1a), 69.6% (T1b), 62.7% (T2), 60.8% (T3), 88.0% (T4a), and 88.7% (T4b), with an average of 75.5%. Ultrasonic T staging sensitivity exceeded 62%, aside from T1b at 40.3%, while specificity was over 91%, except for T3 with 83.5%. The Youden index was above 60%, with T1b and T2 being exceptions. OCEUS T staging corresponded closely with pathology in T4b (kappa > 0.75) and moderately in T1a, T1b, T2, T3, and T4a (kappa 0.40-0.75), registering a concordance rate exceeding 84%. CONCLUSION OCEUS was effective, reliable, and accurate in diagnosing the preoperative T staging of GC. As a noninvasive diagnostic technique, OCEUS merits clinical popularization. |
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| Bibliography: | Author contributions: Liang Y, Jing WY, Song J, Wei QX, Cai ZQ, Li J, Wu P, Wang D, and Ma Y collaboratively conceived and designed the study; Liang Y, Jing WY, Song J, and Wei QX carried out data collection and ultrasound image analysis; Li J was in charge of pathological analysis and interpretation of results; Wu P and Cai ZQ were responsible for data analysis and statistical evaluation; Ma Y, Wang D, and Liang Y drafted the manuscript. All authors have read and approved the final manuscript. Liang Y and Jing WY jointly took charge of the research analysis and implementation, performed data analysis, and co-authored the initial draft of the manuscript. They made equal and significant contributions to the successful completion of the project, thus being recognized as co-first authors. Wang D and Ma Y, as co-corresponding authors, played pivotal roles in experimental design, data interpretation, and manuscript preparation. Wang D oversaw the entire project, conducted literature searches, and revised and submitted the initial manuscript focusing on the clinical application of OCEUS in gastric cancer T staging. Ma Y significantly contributed to the in-depth analysis of OCEUS data, re-interpretation of results, meticulous creation of figures, and comprehensive literature review and synthesis. Her work provided a solid data support and theoretical foundation for the current manuscript, enabling it to focus more on evaluating the accuracy and reliability of OCEUS in preoperative T staging diagnosis of gastric cancer. The collaboration between Wang D and Ma Y is crucial for the publication of this manuscript and other manuscripts currently in preparation. Co-first authors: Yu Liang and Wan-Yi Jing. Corresponding author: Yi Ma, MSc, Doctor, Department of Ultrasound, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32 West Second Section, First Ring Road, Qingyang District, Chengdu 610072, Sichuan Province, China. tougao20220918@126.com Co-corresponding authors: Dong Wang and Yi Ma. |
| ISSN: | 1007-9327 2219-2840 |
| DOI: | 10.3748/wjg.v30.i41.4439 |