Nutrient regulation of the islet epigenome controls adaptive insulin secretion

• Published in: bioRxiv
• Main Authors: Wortham, Matthew, Liu, Fenfen, Fleischman, Johanna Y, Wallace, Martina, Mulas, Francesca, Vinckier, Nicholas K, Harrington, Austin R, Cross, Benjamin R, Chiou, Joshua, Patel, Nisha A, Sui, Yinghui, Jhala, Ulupi S, Shirihai, Orian S, Huising, Mark O, Gaulton, Kyle J, Metallo, Christian M, Sander, Maike
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.08.2019
• Subjects: Acetylation; Adaptation; Beta cells; Blood glucose; Chromatin; Clonal deletion; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Gene regulation; Genetic diversity; Glucose; Homeostasis; Insulin; Insulin secretion; Secretion; Transcription

Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient-stimulated histone acetylation plays a key role in adapting insulin secretion through...