ANALYSIS OF THE IMMUNOEXPRESSION OF IL-17 AND IL-23 IN THYROID DISEASES

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 134; no. 3; p. e214
• Main Authors: Silva, Natália Rodrigues, De Sena Costa, Heloisa Espínola, Da Silva Barros, Caio César, De Melo Fernandes Almeida, Dennys Ramom, Barboza, Carlos Augusto Galvão, Pereira, Joabe Dos Santos, Da Costa Miguel, Márcia Cristina
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2022
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2022.01.669

This research aimed to evaluate the immunoexpression of IL-17 and IL-23 proteins in papillary thyroid carcinomas (PTCs), follicular adenomas (FAs), colloid goiters (CGs), and Hashimoto's thyroiditis (HTs; isolated and associated with PTCs or GCs) in order to better understand the role of these cytokines in these entities. The sample consisted of 30 cases of PTCs, 10 FAs, 15 CGs and 15 HTs. The analysis of protein immunoexpression in follicular/tumor cells with cytoplasmic marking, under 400 × magnification, was semiquantitatively performed in all lesions, which were classified using 3 scores: 1 (≤33%), 2 (>33%-66%) and 3 (>66%). In the evaluation of IL-23, a higher immunostaining of follicular/tumor cells in HTs was detected in relation to PTCs (P = .002). In addition, a statistically significant correlation between the immunoexpression of IL-17 and IL-23 in both follicular/tumor cells (r = 0.539; P = .038) of the HTs was observed. It is suggested that IL-17 and IL-23 influence the pathogenesis of these thyroid lesions and that in some of them they may represent an action of the TH17 immune response.