INVESTIGATING THE ADVANCEMENTS IN MESENCHYMAL STEM CELLS AND THEIR SECRETOME: UNVEILING THE POTENTIAL FOR FACIAL REJUVENATION

• Published in: Cytotherapy (Oxford, England) Vol. 26; no. 6; pp. S61 - S62
• Main Authors: Yusnita, A.V., Faustina, P., Sartika, C.R., Chouw, A., Devi, D.K., Haifa, R., Shabrina, A., Rahmat, S.M., Jundan, S.F., Shyallala, R.A., Arofah, A.N., Facicilia, G., Agustina, R., Kalasuba, K.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2024
• Subjects: Mesenchymal Stem Cells; Secretome; Skin Rejuvenation; Skin Rejuvenation; Secretome; Mesenchymal Stem Cells
• ISSN: 1465-3249; 1477-2566
• DOI: 10.1016/j.jcyt.2024.03.109

Skin aging manifests as decreased function, heightened fragility, and impaired wound healing. The investigation of innovative therapies has been driven by the need to discover effective methods of tissue rejuvenation and anti-aging. Mesenchymal stem cells (MSCs) and their secretomes have been demonstrated for the treatment of aged and damaged skin because of their inherent healing capabilities, which have elevated them to the status of highly promising candidates for anti-aging therapies. However, the use of MSCs and their secretomes as skin aging therapy requires further investigation. This study aims to evaluate the current state of research regarding the use of MSCs and their secretome for facial rejuvenation. Advancements in regenerative medicine present an opportunity to investigate these treatments, which may yield novel and efficacious outcomes. The study included a cohort of six participants, comprising individuals of both men and women, exhibiting diverse skin conditions. During a period of three weeks, the participants were administered MSC injections in the initial week, followed by secretome treatments in the subsequent two weeks. It is recommended to apply sunscreen regularly and utilize a skincare mask after undergoing injections. Reevaluation of skin parameters encompassing pore size, wrinkles, pigmentation, sebum levels in the U-Zone, and sebum levels in the T-Zone was conducted utilizing the Janus-III Facial Analysis System. Significant enhancements were observed upon injection of mesenchymal stem cells (MSCs), such as diminished pigmentation and a reduction in pore size. While no variations were observed in the results on sebum and wrinkles, it was apparent that each group underwent a considerable decrease in the production of excessive sebum and fine lines of wrinkles. There were no adverse events reported, and the participants demonstrated an overall decrease in inflammation and redness. Both mesenchymal stem cells (MSCs) and their secretome exhibited effectiveness in ameliorating signs of skin aging throughout the two-week monitoring period, indicating the possibility of prolonged treatment durations. However, additional clinical evidence is required to determine the exact mechanism by which they operate and their efficacy concerning facial rejuvenation.