Comparative Evaluation to Assess the Effect of SRP With or Without Human Placental Extracts as Local Drug Delivery in Treatment of Localized Periodontal Pocket- A Randomized Controlled Clinical Trial

• Published in: International Journal of Dentistry Research Vol. 5; no. 2; pp. 66 - 70
• Main Authors: Sharma, Aakriti, Sharma, Sanjeev, Nagar, Amit
• Format: Journal Article
• Language: English
• Published: 25.08.2020
• ISSN: 2581-3218; 2581-3218
• DOI: 10.31254/dentistry.2020.5208

Background: Periodontal disease is one of the most prevalent global chronic disorder. Pathology affecting the structure surrounding teeth results in inflammation initiated by bacterial aggregation & alteration in their profile. Conventional periodontal therapeutics has focused on the control of etiologic agents, thereby promoting healing & repair of tissues. Delivery of therapeutic agents into the local milieu act as drug reservoirs which could alter pathogenic flora & promote its repair & wound healing. Aim & Objective: In an effort to develop a novel therapy, the present study aims to compare clinical soft tissue parameters around periodontal pockets treated with & without human placental extracts delivered locally. Materials & Method: In 10 patients of chronic periodontitis, bilateral localized periodontal pockets of 4-6 mm depth were included. Each site was randomly allocated to group 1 & group 2,where in group 1, scaling & root planing( SRP) was done while in group 2,Placentrex Gel (Human placental extracts) adsorbed on absorbable gelatin matrix (Abgel) used as a vehicle was delivered as an adjunct to SRP . Clinical parameters were recorded & re- evaluated after one month for both the treatment groups . Statistical analysis was carried out to evaluate the effect of Placentrex gel as an adjunct to SRP in treatment of periodontal pockets, Mann Whitney & Paired t test were done. Results: There was a statistically significant improvement in clinical parameters with notable difference in probing depth reduction & gain of clinical attachment level in the treatment group subjected to SRP & Placental extract delivery. Conclusion: Clinical variables showed a greater efficacy of SRP & adjunctive use of placental extracts as compared to conventional treatment by SRP thereby underlying placental extracts usage in the management of periodontal disease condition