RECURRENT LANGERHANS CELL HISTIOCYTOSIS IN JAWBONES: A CASE REPORT

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells. The jawbones are involved in about 20-30% of all skeletal cases. A 27-year-old female patient presented multiple lesions in the maxilla and mandible from 2012 to 2021...

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Published inOral surgery, oral medicine, oral pathology and oral radiology Vol. 136; no. 1; p. e70
Main Authors GOMES, Isadora Pereira, SCHMITZ, João Ayres de Souza, SILVA, Tarcília Aparecida, RESENDE, Renata Gonçalves, de LACERDA, Júlio César Tanos
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.07.2023
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Summary:Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells. The jawbones are involved in about 20-30% of all skeletal cases. A 27-year-old female patient presented multiple lesions in the maxilla and mandible from 2012 to 2021. Radiographically, the lesions appear in a lytic form. An incisional biopsy was performed and confirmed the diagnosis of LCH, showing proliferation of large, round to oval mononuclear cells with an epithelioid shape, with eosinophilic cytoplasm and a grooved nucleus. The treatment consisted of intralesional corticosteroid therapy, a surgical approach, and chemotherapy. The last recurrence was diagnosed 5 months ago, and the patient is being prepared for another surgical treatment.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2023.03.247