METASTATIC RENAL CLEAR-CELL CARCINOMA PRESENTING AS A PYOGENIC GRANULOMA

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; p. e56
• Main Authors: MEZA, TANIA MONTSERRAT SÁNCHEZ, LÓPEZ, BLANCA SILVIA GONZÁLEZ, CUELLAR, ANA GUADALUPE GAMA, HERNÁNDEZ, REY ROMÁN CEDILLO, QUIROGA, SILVIA CRISTINA MANZUR, CARRILLO, EDITH LARA, RIZO, VÍCTOR HUGO TORAL
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.204

Metastatic tumors of the oral mucosa are infrequent and represent approximately 1% of all oral neoplasms. Renal clear-cell carcinoma (RCCC) is the third most common metastatic tumor in the mouth and it can mimic a pyogenic granuloma. A 51-year-old man was referred due to an oral lesion involving the vestibular gingival region of teeth 23 to 22, with clinical diagnosis of pyogenic granuloma. An excisional biopsy was made, histopathologic features revealed a malignant neoplasm of clear cells. Immunohistochemical analysis was carried out in order to discard metastasis of RCCC. The neoplastic cells were positive for CD10, AE1/AE3, EMA, vimentin, and Ki-67. In addition, a coexpression between CD10, AE1/AE3, and vimentin antibodies was observed. With these findings, the diagnosis of metastatic RCCC was established and the patient was sent to an oncology hospital. The diagnosis of an oral metastasis is associated with poor prognosis due to the multiple organ involvement.