A MANDIBULAR NEUROENDOCRINE TUMOR, POORLY DIFFERENTIATED

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; pp. e37 - e38
• Main Authors: TORAL-RIZO, VÍCTOR HUGO, MARTÍNEZ-VARGAS, DANIEL, LARA-CARRILLO, EDITH, VELÁZQUEZ-ENRÍQUEZ, ULISES, SCOUGALL-VILCHIS, ROGELIO JOSÉ, MANZUR-QUIROGA, SILVIA CRISTINA, ROBLES-BERMEO, NORMA LETICIA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.112

Neuroendocrine tumors constitute a heterogeneous group of lesions, which are extremely rare in the oral cavity. A 70-year-old male patient reported a chief complaint of a swelling in the mouth. Intraoral examination revealed a nodule in the anterior region of the right jaw over the alveolar ridge of approximately 3 × 2.5 cm. Computed tomography demonstrated a hypodense destructive lesion. An incisional biopsy was done and the histopathologic findings described a poorly differentiated malignant neoplasm without neural invasion. Immunohistochemical analysis was requested and the results showed positivity for the antibodies CD10, SYN, chomogranin, with a strong staining for Ki67, and focal staining for vimentin. The CK20, cytokeratin AE1/AE3, PSA, and CK7 antibodies were negative. The patient was referred to an oncology hospital. Immunohistochemistry is a highly sensitive method for the diagnosis of neuroendocrine tumors. A mix of surgery, multidrug chemotherapy, and radiotherapy are used for treatment.