Sonographic Findings in Congenital Zika Virus Infection: Cohort Study [4P]

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 129; no. Suppl 1; pp. S164 - S165
• Main Authors: Suely de Oliveira Melo, Adriana, Carneiro, Juliana Garcia, de Oliveira Melo, Fabiana, Bianka de Souza Manhães, Cláudia, Silva, Mariana Balbino, Amorim, Melania M.
• Format: Journal Article
• Language: English
• Published: Lippincott Williams & Wilkins 01.05.2017
• ISSN: 0029-7844
• DOI: 10.1097/01.AOG.0000514077.54388.3c

INTRODUCTION: The Congenital Zika Virus Infection was first observed in the Northeast of Brazil, being confirmed by amniocentesis in November 2015. From the first findings characterized by microcephaly, ventriculomegaly, arthrogryposis and injuries of posterior fossa, other findings were being identified. METHODS: A prospective cohort study that followed 500 pregnant women with symptoms suggestive of ZikV. The women collected blood and urine to search ZikV by RT-PCR and they were submitted to ultrasound and came to the service. We also evaluated ultrasound performed in other services. The ultrasounds were performed in Samsung WS80 Elite. RESULTS: Among the 500 pregnant women evaluated, 96 showed positive PCR for Zika and 32 had some brain damage. The mean gestational age of the first finding was 27 weeks, with a minimum age of 14 weeks. The most common early finding was mild ventriculomegaly, followed by calcifications and changes of posterior fossa. Arthrogryposis was observed in severe cases. The mean age at diagnosis of microcephaly, when present, was 28 weeks. The average age at birth was 39 weeks, ranging from 29 to 42 weeks. The average head circumference was 30 cm ranging from 23 to 36 cm and the mean birth weight was 2775 grams, ranging between 1060 and 3770 grams. CONCLUSION: Despite microcephaly is the most frequent sign of the syndrome of congenital Zika, it is generally not the first sign and is not always present.