Eya2 expression during mouse embryonic development revealed by Eya2 lacZ knockin reporter and homozygous mice show mild hearing loss

• Published in: Developmental dynamics Vol. 250; no. 10; pp. 1450 - 1462
• Main Authors: Zhang, Ting, Xu, Jinshu, Xu, Pin‐Xian
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Animals; Cell Differentiation - physiology; Ear, Inner - embryology; Ear, Inner - metabolism; Embryonic Development - genetics; Gene Expression Regulation, Developmental; Hearing Loss - genetics; Hearing Loss - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Mice; Mice, Knockout; Mice, Transgenic; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Protein Tyrosine Phosphatases - genetics; Protein Tyrosine Phosphatases - metabolism; salivary gland; ocular/trochlear motor neurons; neural crest cells; thymus; Eya2; hearing loss; cranial placodes; cranial sensory ganglia; inner ear hair cells; sensory organs
• ISSN: 1058-8388; 1097-0177
• DOI: 10.1002/dvdy.326

X‐gal staining of Eya2‐lacZ reporter reveals reporter expression in oculomotor and trochlear motor neurons, cranial ganglia, differentiating inner ear hair cells, salivary gland and thymus. Eya2‐null mice show hearing loss and smaller thymus. Our results highlight that Eya2 as a potential regulator may act synergistically with other Eya genes to regulate the differentiation of the inner ear sensory hair cells and the formation of the salivary gland and thymus.