Unchanged cerebrovascular CO 2 reactivity and hypercapnic ventilatory response during strict head‐down tilt bed rest in a mild hypercapnic environment

• Published in: The Journal of physiology Vol. 598; no. 12; pp. 2491 - 2505
• Main Authors: Laurie, Steven S., Christian, Kate, Kysar, Jacob, Lee, Stuart M.C., Lovering, Andrew T., Macias, Brandon R., Moestl, Stefan, Sies, Wolfram, Mulder, Edwin, Young, Millennia, Stenger, Michael B.
• Format: Journal Article
• Language: English
• Published: England 01.06.2020
• Subjects: Astronauts; Bed Rest - adverse effects; Carbon Dioxide; Female; Head-Down Tilt; Humans; Hypercapnia; carbon dioxide; spaceflight; cerebral blood flow; bed rest; hypercapnia
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/JP279383

Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head‐down tilt bed rest model of spaceflight and this led to the development of optic d...