Unchanged cerebrovascular CO 2 reactivity and hypercapnic ventilatory response during strict head‐down tilt bed rest in a mild hypercapnic environment

Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head‐down tilt bed rest model of spaceflight and this led to the development of optic d...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of physiology Vol. 598; no. 12; pp. 2491 - 2505
Main Authors Laurie, Steven S., Christian, Kate, Kysar, Jacob, Lee, Stuart M.C., Lovering, Andrew T., Macias, Brandon R., Moestl, Stefan, Sies, Wolfram, Mulder, Edwin, Young, Millennia, Stenger, Michael B.
Format Journal Article
LanguageEnglish
Published England 01.06.2020
Subjects
Astronauts
Bed Rest - adverse effects
Carbon Dioxide
Female
Head-Down Tilt
Humans
Hypercapnia
carbon dioxide
spaceflight
cerebral blood flow
bed rest
hypercapnia
Online AccessGet full text

Cover

More Information
Summary:Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head‐down tilt bed rest model of spaceflight and this led to the development of optic disc oedema in one‐half of the subjects. We demonstrate no change in arterialized , cerebrovascular reactivity to CO 2 or the hypercapnic ventilatory response. Our data suggest that the mild hypercapnic environment does not contribute to the development of spaceflight associated neuro‐ocular syndrome.
ISSN:0022-3751
1469-7793
DOI:10.1113/JP279383