High-Contrast and Fast-Removable 19 F-MRI Labels with Perfluoro-tert-Butyl Substituents
F MRI is a unique technique for tracking and quantifying the indicator ( F-MRI label) in vivo without the use of ionizing radiation. Here we report new F-MRI labels, which are compounds with perfluoro-tert-butyl groups: 1,2-bis(perfluoro-tert-butoxy)ethane (C F H O ) and 1,3-bis(perfluoro-tert-butyl...
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Published in | ChemMedChem Vol. 18; no. 18; p. e202300239 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
15.09.2023
|
Subjects | |
Online Access | Get full text |
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Summary: | F MRI is a unique technique for tracking and quantifying the indicator (
F-MRI label) in vivo without the use of ionizing radiation. Here we report new
F-MRI labels, which are compounds with perfluoro-tert-butyl groups: 1,2-bis(perfluoro-tert-butoxy)ethane (C
F
H
O
) and 1,3-bis(perfluoro-tert-butyl)propane (C
F
H
). Both substances contain 18 equivalent
F atoms, constituting 68.67 % and 71.25 % of the molecule, respectively. The emulsions with
F molecules were prepared and used in
F MRI studies in laboratory rats in vivo. The substances demonstrated high contrast properties, good biological inertness and the ability to be rapidly eliminated from the body. We showed that at a dose of 0.34 mg/g of body weight in rats, the time for complete elimination of C
F
H
O
and C
F
H
is ∼30 days. The results turned out to be promising for the use of the presented compounds in
F MRI applications, especially since they are quite easy to synthesize. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1860-7179 1860-7187 |
DOI: | 10.1002/cmdc.202300239 |