Genetic loci influencing kidney function and chronic kidney disease in man

• Published in: Nature genetics Vol. 42; no. 5; pp. 373 - 375
• Main Authors: Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S, Gale, Daniel P, Wass, Mark N, Ahmadi, Kourosh R, Bakker, Stephan JL, Beckmann, Jacqui, Bilo, Henk JG, Bochud, Murielle, Brown, Morris J, Caulfield, Mark J, Connell, John M C, Cook, Terence, Cotlarciuc, Ioana, Smith, George Davey, de Silva, Ranil, Deng, Guohong, Devuyst, Olivier, Dikkeschei, Lambert D., Dimkovic, Nada, Dockrell, Mark, Dominiczak, Anna, Ebrahim, Shah, Eggermann, Thomas, Farrall, Martin, Ferrucci, Luigi, Floege, Jurgen, Forouhi, Nita G, Gansevoort, Ron T, Han, Xijin, Hedblad, Bo, van der Heide, Jaap J Homan, Hepkema, Bouke G, Hernandez-Fuentes, Maria, Hypponen, Elina, Johnson, Toby, de Jong, Paul E, Kleefstra, Nanne, Lagou, Vasiliki, Lapsley, Marta, Li, Yun, Loos, Ruth J F, Luan, Jian'an, Luttropp, Karin, Maréchal, Céline, Melander, Olle, Munroe, Patricia B, Nordfors, Louise, Parsa, Afshin, Penninx, Brenda W., Perucha, Esperanza, Pouta, Anneli, Prokopenko, Inga, Roderick, Paul J, Ruokonen, Aimo, Samani, Nilesh, Sanna, Serena, Schalling, Martin, Schlessinger, David, Schlieper, Georg, Seelen, Marc AJ, Shuldiner, Alan R, Sjögren, Marketa, Smit, Johannes H., Snieder, Harold, Soranzo, Nicole, Spector, Timothy D, Stenvinkel, Peter, Sternberg, Michael JE, Swaminathan, Ramasamyiyer, Tanaka, Toshiko, Ubink-Veltmaat, Lielith J., Uda, Manuela, Vollenweider, Peter, Wallace, Chris, Waterworth, Dawn, Zerres, Klaus, Waeber, Gerard, Wareham, Nicholas J, Maxwell, Patrick H, McCarthy, Mark I, Jarvelin, Marjo-Riitta, Mooser, Vincent, Abecasis, Goncalo R, Lightstone, Liz, Scott, James, Navis, Gerjan, Elliott, Paul, Kooner, Jaspal S
• Format: Journal Article
• Language: English
• Published: 11.04.2010
• ISSN: 1061-4036; 1546-1718
• DOI: 10.1038/ng.566

Chronic kidney disease (CKD), the result of permanent loss of kidney function, is a major global problem. We identify common genetic variants at chr2p12-p13, chr6q26, chr17q23 and chr19q13 associated with serum creatinine, a marker of kidney function (P=10 −10 to 10 −15 ). SNPs rs10206899 (near NAT8 , chr2p12-p13) and rs4805834 (near SLC7A9 , chr19q13) were also associated with CKD. Our findings provide new insight into metabolic, solute and drug-transport pathways underlying susceptibility to CKD.