Commentary: the perspectives of harnessing the power of scattered tubular-like cells for renal repair

The commentary discusses the regenerative capacity of the kidneys; recent studies reveal that renal cells can regenerate when exposed to certain conditions. A major focus is on scattered tubular-like cells (STCs), which can dedifferentiate and acquire progenitor-like properties in response to injury...

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Bibliographic Details
Published inClinical science (1979) Vol. 138; no. 21; p. 1371
Main Authors Jones, Adam C, Palygin, Oleg, Ilatovskaya, Daria V
Format Journal Article
LanguageEnglish
Published England 06.11.2024
Subjects
Animals
Humans
Kidney
Kidney Diseases - pathology
Kidney Diseases - therapy
Kidney Tubules - cytology
Kidney Tubules - metabolism
Regeneration - physiology
Stem Cells - physiology
Regeneration
Injury repair
Scattered tubular-like cells
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Summary:The commentary discusses the regenerative capacity of the kidneys; recent studies reveal that renal cells can regenerate when exposed to certain conditions. A major focus is on scattered tubular-like cells (STCs), which can dedifferentiate and acquire progenitor-like properties in response to injury. These cells exhibit a glycolytic metabolism, making them resilient to hypoxic conditions and capable of repairing damaged renal tissues. Despite their potential, STCs are difficult to isolate and exist in small numbers. Here we highlight the need for more research into STC function, metabolic profiles, mechanisms limiting STC injury repair capacity, and methods of their pharmacological activation. Understanding these mechanisms could lead to novel therapies for kidney diseases.
ISSN:1470-8736
DOI:10.1042/CS20241405