Formulation and Characterization of Cerium Ion Cross‐Linked Alginate/ PVA Films for Wound Dressing Applications

• Published in: Biopolymers Vol. 116; no. 5; p. e70043
• Main Authors: Kahya, Nilay, Öztekin, Nevin, Gürarslan, Alper
• Format: Journal Article
• Language: English
• Published: United States 01.09.2025
• Subjects: Alginates - chemistry; Bandages; Biocompatible Materials - chemistry; Cerium - chemistry; Cross-Linking Reagents - chemistry; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Permeability; Polyvinyl Alcohol - chemistry; Spectroscopy, Fourier Transform Infrared; Steam; Wound Healing - drug effects; biopolymer; poly(vinyl) alcohol; acid treatment; wound dressing; cerium(III) carbonate
• ISSN: 0006-3525; 1097-0282; 1097-0282
• DOI: 10.1002/bip.70043

Herein, alginate films doped with cerium(III) carbonate were prepared via the casting method. An acid treatment process was applied to the films for cross‐linking by free Ce 3+ ions. The incorporation of poly(vinyl) alcohol into the alginate matrix enhanced the film properties. Fourier transform infrared spectroscopy and differential scanning calorimetry analyses confirmed that PVA did not alter the chemical structure of the Ce/Alg films. Analysis of the morphological characteristics of Ce/Alg films using a scanning electron microscope revealed that porosity existed in the films. Cerium‐alginate films rapidly swell in PBS (pH = 7.4) and water within 10 min, demonstrating their potential for effective fluid absorption in wound environments. The water vapor permeability test exhibited that the films have the ability to transmit moisture. This present work reports the formulation of cerium(III) cross‐linked alginate films and characterization studies of the films. The films are regarded as subject to efficient wound coverage dressings in future studies with their favorable biomaterial properties.