Pharmacokinetics of Cisplatin and its Metabolites Following Intravenous Administration in Cancer Patients of Bangladesh
Background: To determine the mean bioavailability of cisplatin at different time interval after intravenous administration of cisplatin of 18-60 years old 50 male Bangladeshi cancer patients.Materials & Methods: Pharmacokinetic and demographic data were collected from 50 various types of male ca...
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Published in | KYAMC Journal Vol. 9; no. 3; pp. 110 - 114 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
04.12.2018
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Online Access | Get full text |
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Summary: | Background: To determine the mean bioavailability of cisplatin at different time interval after intravenous administration of cisplatin of 18-60 years old 50 male Bangladeshi cancer patients.Materials & Methods: Pharmacokinetic and demographic data were collected from 50 various types of male cancer patients received injection cisplatin 50 mg/m2 infusion for over 3 hours every alternate week for 3 weeks and mean population bioavailability were determined.Results: Statistical analysis from data of HPLC reported that the highest mean plasma concentration of cisplatin was found 428.32 μg/dl (±6.092) after 3 hours and highest mean urinary concentration of cisplatin was found 996.56μg/dl (±1.97) after 12 hours (P<0.05). Highest and lowest concentration of four suspected metabolites (CM2, CM3, CM4 and CM5) were identified in blood and corresponding urine with their specific RT (retention time) and Area (P<0.01) which suggestive of previous work.Conclusion: Following I/V administration plasma concentration of cisplatin at different time interval determined the proper dosing dosing interval of the drug and reduce toxicity.KYAMC Journal Vol. 9, No.-3, October 2018, Page 110-114 |
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ISSN: | 2308-2720 2308-2860 |
DOI: | 10.3329/kyamcj.v9i3.38781 |