Statherin-derived peptide protects against intrinsic erosive enamel wear in situ
This in situ study investigated the protective effect of a solution containing statherin-derived peptide (StatpSpS) against enamel intrinsic erosion. Fifteen volunteers wore appliances containing 2 bovine specimens. The samples were subjected to erosion (ERO) with HCl, mimicking dental erosion by in...
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Published in | Caries research p. 1 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
12.09.2024
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Online Access | Get more information |
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Summary: | This in situ study investigated the protective effect of a solution containing statherin-derived peptide (StatpSpS) against enamel intrinsic erosion.
Fifteen volunteers wore appliances containing 2 bovine specimens. The samples were subjected to erosion (ERO) with HCl, mimicking dental erosion by intrinsic acid. The volunteers participated in 3 phases (double-blind and crossover): 1) Deionized water (negative control); 2) Commercial solution containing SnCl2/NaF/AmF (800 ppm Sn+2, 500 ppm F-, pH 4.5) - (positive control); 3) Solution containing 1.88 X 10-5M StatpSpS. Four times a day, the volunteers administered one drop of the solutions (50 µl, 1 min) on each specimen. After the treatment, erosive challenges were performed extraorally with 0.01 M HCl (pH 2.0, 4 times/day, 1 min, 150 mL). Enamel wear was assessed by profilometry. Data was analyzed by one-way RM-ANOVA/Bonferroni's tests (p<0.05).
In terms of the treatments, both the commercial solution - SnCl2/NaF/AmF and StatpSpS significantly reduced the wear when compared to the negative control (p<0.01), without significant differences between them (p>0.05).
The solution containing StatpSpS demonstrated protection against enamel intrinsic erosive wear. This study marks a significant advancement in the prevention of intrinsic erosive wear, utilizing StatpSpS in acquired pellicle engineering procedures. |
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ISSN: | 1421-976X |
DOI: | 10.1159/000541403 |