A T‐Cell Inspired Sonoporation System Enhances Low‐Dose X‐Ray‐Mediated Pyroptosis and Radioimmunotherapy Efficacy by Restoring Gasdermin‐E Expression (Adv. Mater. 26/2024)

Radioimmunotherapy Genome editing has the potential to remodel the immunogenicity of cancer cells, thereby enhancing the efficacy of anti‐tumour immunotherapy. However, the plasma membrane presents a challenge as it impedes the entry of the genome‐editing agent. In article number 2401384, Qinyang Wa...

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Published inAdvanced materials (Weinheim) Vol. 36; no. 26
Main Authors Yin, Hao, Hu, Xiaoqu, Xie, Congying, Li, Yida, Gao, Yanjun, Zeng, Hanqian, Zhu, Wenting, Xie, Danli, Wang, Qinyang
Format Journal Article
LanguageEnglish
Published 26.06.2024
Subjects
genome editing
low‐dose X‐ray
pyroptosis
radioimmunotherapy
T‐cell bionic sonoporation
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Summary:Radioimmunotherapy Genome editing has the potential to remodel the immunogenicity of cancer cells, thereby enhancing the efficacy of anti‐tumour immunotherapy. However, the plasma membrane presents a challenge as it impedes the entry of the genome‐editing agent. In article number 2401384, Qinyang Wang and co‐workers develop a bioinspired sonoporation system to open the cell membrane for aiding genome editing in vitro and in vivo.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202470198