Pharmaceutical Micropellets: A Multi-particulate Drug Delivery System

• Published in: International journal for research in applied science and engineering technology Vol. 11; no. 3; pp. 368 - 381
• Main Authors: Agrawal, Ankit, Jain, Sourabh D, Das, Ashutosh K, Gupta, Arun K
• Format: Journal Article
• Language: English
• Published: 31.03.2023
• ISSN: 2321-9653; 2321-9653
• DOI: 10.22214/ijraset.2023.49427

The major target of Pharmaceutical Sciences is to design a successful and suitable dosage forms for effective therapy, considering individual patient needs and compliance. Development of new technology or development of new dosage form using the existing technology is growing in importance and attracting increased interest, as they are specifically effective at a comparably low dose. Pellets falling in the size range of 1-1000μm are of great interest in the pharmaceutical industry for a variety of reasons which are not only offer flexibility in dosage form design and development, but are also utilized to improve the safety and efficacy of bioactive agents. The most important factor responsible for the proliferation of pelletized products is the popularity of controlled release technology in the delivery of drugs. Moreover, controlled release pellets are less susceptible to dose dumping than the reservoir-type single unit formulations. In case of oral products these pellets solve difficult taste-masking problems, disperse freely in the gastro intestinal tract, invariably maximize drug absorption, reduce peak plasma fluctuations and minimize potential side effects without appreciably lowering drug bioavailability, and also reduce variations in gastric emptying rate and overall transit time, thus, intra and inter subject variability of plasma profiles, which are common with single unit regimens, are minimized.