Cover Feature: Bidentate Disilicate Framework for Bis‐Grafted Surface Species (Chem. Eur. J. 47/2021)

Synthesizing the “wanted” bald eagle killer: Aetokthonotoxin (AETX), a pentabrominated 1,2’‐biindole alkaloid has been indicted to elicit vacuolar myelinopathy, a neurologic disease causing the death of birds of prey, such as the bald eagle in the USA. In order to assess further biological activity...

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Bibliographic Details
Published inChemistry : a European journal Vol. 27; no. 47; p. 12009
Main Authors Ishizaka, Yusuke, Arai, Natsumi, Matsumoto, Kazuhiro, Nagashima, Hiroki, Takeuchi, Katsuhiko, Fukaya, Norihisa, Yasuda, Hiroyuki, Sato, Kazuhiko, Choi, Jun‐Chul
Format Journal Article
LanguageEnglish
Published 19.08.2021
Subjects
bis-grafted surface species
disilicate ligands
grafting on silicon atoms
six-membered rings
surface organometallic chemistry
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Summary:Synthesizing the “wanted” bald eagle killer: Aetokthonotoxin (AETX), a pentabrominated 1,2’‐biindole alkaloid has been indicted to elicit vacuolar myelinopathy, a neurologic disease causing the death of birds of prey, such as the bald eagle in the USA. In order to assess further biological activity studies, synthesis of this neurotoxin is decidedly needed. Here, we describe its first total synthesis: by fusing advanced indole intermediates in a Somei‐type Michael reaction in only five steps overall. More information can be found in the Full Paper by M. G. Ricardo, B. Westermann, et al. (DOI: 10.1002/chem.202101848).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202102615