Antihistamine: New Advancement in H1&H2 Receptor used for Pregnancy

• Published in: International journal for research in applied science and engineering technology Vol. 11; no. 6; pp. 4576 - 4582
• Main Authors: Koundal, Abhay, Saini, Ritika, Ashawat, Dr. M.S, Kumari, Ms. Dimple
• Format: Journal Article
• Language: English
• Published: 30.06.2023
• ISSN: 2321-9653; 2321-9653
• DOI: 10.22214/ijraset.2023.54354

The function of histamine in allergic inflammation, neurotransmission, and immunological regulation has since been better known one of the most typical skin conditions is urticaria. It may be sudden, recurring, caused by physical stimulation, or brought on by contact with an urticant. A small vessel vasculitis may be the cause of certain instances. As knowledge about this disorder grows, autoimmune pathways are now understood to contribute to chronic urticaria. This study shows that H antihistamine therapy alone is not statistically better to combined H2 and H antihistamine therapy for the treatment of chronic urticaria symptoms. Histamine has been one of the biological amines most extensively studied in medicine. It encourages the contraction of smooth muscles and the release of stomach acid, enhances vascular permeability, functions as a neurotransmitter, and has a range of actions in the control of the immune system, allergies, inflammation, haematopoiesis, and cell division. Histamine works by attaching to the H1, H2, H3, and H4 receptors. H3 and H4 receptors are predominantly presynaptic and haematopoietic, respectively, whereas H1 and H2 receptors are widely dispersed. Human H1- and H2-histamine receptors were cloned and described in the early 1990s, followed a few years later by human H3- and H4-histamine receptors. The main treatment for chronic urticaria is second-generation non-sedating non-impairing H antihistamines. Then, the H antihistamines permitted dosage is raised by a factor of up to four