ASEPTIC SKIN NECROSIS OF THE RIGHT UPPER EXTREMITY IN A PATIENT WITH ACUTE MYELOBLASTIC LEUKEMIA: A CLINICAL CASE REPORT

• Published in: Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії Vol. 25; no. 2; pp. 194 - 196
• Main Authors: Pilat, I.O., Skrypnyk, I.M., Maslova, G.S.
• Format: Journal Article
• Language: English
• Published: 29.05.2025
• ISSN: 2077-1096; 2077-1126
• DOI: 10.31718/2077-1096.25.2.194

We describe a rare case of aseptic necrosis lesion of the right upper extremity in a patient with acute myeloblastic leukemia. The lesion developed 2 months after the appearance of the first symptoms. The disease was characterized by general weakness, night sweats, rapid fatigue, lack of strength, shortness of breath with minor physical exertion, periodic bleeding of the nasal mucosa and gums, the appearance of ulcers on the oral mucosa, an increase in body temperature to 38°C, the appearance of bruises on the skin of the trunk and extremities, which arose spontaneously without trauma. Then the patient noted the appearance of edema, severe pain, redness of the right upper limb. During the examination, the patient was found to have severe leukopenia and severe neutropenia. According to the laboratory examination, the diagnosis of acute myeloblastic leukemia was confirmed. Skin lesions of the right upper limb, observed at the onset of acute myeloblastic leukemia, were characterized by the development of aseptic necrosis. The emergence of acute myeloblastic leukemia complicated by secondary cutaneous involvement in the form of aseptic necrosis may be considered an unfavorable prognostic factor, often associated with resistance to specific chemotherapy.