Metabolic changes in white rats with active and passive behavior types subject to long-term cadmium exposure

• Published in: Experimental and Clinical Physiology and Biochemistry Vol. 103; no. 1-2; pp. 44 - 49
• Main Author: FEDORENKO, YU. V.
• Format: Journal Article
• Language: English
• Published: 01.07.2025
• ISSN: 1609-6371; 2415-3176
• DOI: 10.25040/ecpb2025.01-02.044

Cadmium intake can cause disruption of adaptive processes and contribute to the development of various pathologies. The features of the CNS determine the individualization of the body’s response to factors of any nature. Aim of the study. To investigate the dynamics of calcium, glucose, cholesterol concentration, alkaline phosphatase, alanine and aspartate aminotransferase activity in the blood serum of white rats with active and passive behavior types subject to long-term exposure to cadmium. Materials and methods. The type of behavior was determined by the «open field» test. Aqueous solutions of cadmium sulfate were administered daily on an empty stomach at a dose of 10 mg/kg of body weight for 30 days. On the 3rd, 5th, 10th and 30th day of the experiments, the total calcium, cholesterol, glucose concentration, alkaline phosphatase and aminotransferase activity in the blood serum were determined. Results. It was found that cadmium leads to a decrease in serum calcium concentration and an increase in glucose, cholesterol and aminotransferase activity in both groups of animals, but to a greater extent in passive ones. Alkaline phosphatase activity changed in a wave-like manner. The maximum changes were recorded at the end of the experiments for all studied indicators. Hypocalcemia and multidirectional changes in alkaline phosphatase activity characterize the processes of decreasing the mineral density of the bone system. Increased enzyme activity, glucose concentration, cholesterol indicate damage to the liver, pancreas with a higher metabolic intensity in animals with an active type of behavior. The effect of cadmium in the group of passive animals can lead to the development of osteoporosis more quickly than in the active ones. Conclusions. The intensity, direction and development over time of the studied indicators depend on the level of spontaneous activity. White rats with active behavior type are more resistant to the effects of cadmium