The early days of ex vivo 1 H, 13 C, and 31 P nuclear magnetic resonance in the laboratory of Dr. Robert G. Shulman from 1975 to 1995

This paper provides a brief description of the early use of ex vivo nuclear magnetic resonance (NMR) studies of tissue and tissue extracts performed in the laboratory of Dr. Robert G. Shulman from 1975 through 1995 at Bell Laboratories, then later at Yale University. During that period, ex vivo NMR...

Full description

Saved in:
Bibliographic Details
Published inNMR in biomedicine Vol. 36; no. 4; p. e4879
Main Authors Rothman, Douglas L, Behar, Kevin L, Petroff, Ognen A C, Shulman, Robert G
Format Journal Article
LanguageEnglish
Published England 01.04.2023
Subjects
Animals
Humans
Laboratories
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy - methods
Mammals
magnetic resonance spectroscopy
31P MRS
metabolism
resonance assignment
1H MRS
13C MRS
Online AccessGet full text

Cover

More Information
Summary:This paper provides a brief description of the early use of ex vivo nuclear magnetic resonance (NMR) studies of tissue and tissue extracts performed in the laboratory of Dr. Robert G. Shulman from 1975 through 1995 at Bell Laboratories, then later at Yale University. During that period, ex vivo NMR provided critical information in support of resonance assignments and the quantitation of concentrations for magnetic resonance spectroscopy studies. The period covered saw rapid advances in magnet technology, starting with studies of microorganisms in vertical bore high-resolution NMR studies, then by 1981 studies of small mammals in a horizontal bore magnet, and then studies of humans in 1984. Ex vivo NMR played a critical role in all these studies. A general strategy developed in the lab for using ex vivo NMR to support in vivo studies is presented, as well as illustrative examples.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.4879