Front Cover: Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors (ChemMedChem 9/2022)

The Front Cover shows the development of a potent and selective histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor that was tailor‐made to engage the characteristic “foot‐pocket” present in both isoforms. This was achieved by a modular approach aiming to find the perfect balance between selectivity...

Full description

Saved in:
Bibliographic Details
Published inChemMedChem Vol. 17; no. 9
Main Authors Schäker‐Hübner, Linda, Haschemi, Reza, Büch, Thomas, Kraft, Fabian B., Brumme, Birke, Schöler, Andrea, Jenke, Robert, Meiler, Jens, Aigner, Achim, Bendas, Gerd, Hansen, Finn K.
Format Journal Article
LanguageEnglish
Published 04.05.2022
Subjects
cancer
drug design
epigenetics
histone deacetylases
inhibitors
Online AccessGet full text

Cover

More Information
Summary:The Front Cover shows the development of a potent and selective histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor that was tailor‐made to engage the characteristic “foot‐pocket” present in both isoforms. This was achieved by a modular approach aiming to find the perfect balance between selectivity and drug‐likeliness through systematic screening and thorough biological evaluation. Cover design by Dr. Christoph Selg. More information can be found in the Research Article by Linda Schäker‐Hübner, Finn K. Hansen et al.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202200210