In silico screening of natural compounds from Jatropha curcas (Euphorbiaceae, Linn) and Jatropha gossypifolia (Euphorbiaceae, Linn) against SARS-CoV2, a COVID-19 main protease, using molecular docking approach

• Published in: IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol. 7; no. 3; pp. 148 - 157
• Main Authors: Mulongo, Emmanuel Kitete, Kilembe, Jason T, Bongo, Gedeon Ngiala, Ngbolua, Koto-te-Nyiwa, Dinangayi, Dorothée Tshilanda, Tshibangu, Damien Sha Tshibey, Mpiana, Pius T
• Format: Journal Article
• Language: English
• Published: 25.10.2022
• ISSN: 2540-9395; 2540-9409
• DOI: 10.24845/ijfac.v7.i3.148

SARS-Cov2, the COVID-19 main protease is set to be a good target for potential inhibitors especially from plants. 6LU7, the crystal structure of COVID-19 has been used for docking with natural compounds from Jatropha curcas and Jatropha gossypifolia. The following compounds identified within J. curcas have given good binding affinities than Azythromycin (control sample): 2-methyl anthraquinone, Curcusone D, Palmarumycin CP1, Apigenin, Jatropholone A, Jatropholone B, Spirocurcasone and Multidione. The best score is for Palmarumycin CP1 -8.2 Kcal/mol. All these compounds are R05 satisfied, good HIA scores and good pharmacokinetic properties. In J.gossypifolia, 2,24,25-Trihydroxylanosta-1,7-dien-3-one ; Cleomiscosin A, Citlalitrione, Gossypifan, Jatrophenone, Jatropholone A, Jatropholone B, Gadain, Gossypidien, Falodone and Gossypiline are having good binding affinities than Azythromycin (control sample). The best score is for Cleomiscosin A -8.2 Kcal/mol. All these compounds are R05 satisfied, good HIA scores and good pharmacokinetic properties. This study has shown anti-COVID-19 potential of these two plants.