Genomic Research and Incidental Findings

The Human Genome Project showed that there is signifcant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental fnd‐ings c...

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Bibliographic Details
Published inThe Journal of law, medicine & ethics Vol. 36; no. 2; pp. 292 - 297
Main Author Van Ness, Brian
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 22.06.2008
SAGE Publications
Sage Publications, Inc
Cambridge University Press
Subjects
Base sequence
Bone marrow
Breast cancer
Disclosure - ethics
Disease
Economic problems
Genes
Genetic counseling
Genetic Research - ethics
Genetic Variation - ethics
Genetics
Genomes
Genomics
Genomics - statistics & numerical data
Genomics - trends
Health
Health risk assessment
Human genome
Humans
Incidental Findings
Laboratories
Medical research
Medical treatment
Nucleotide sequence
Paternity
Researchers
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Summary:The Human Genome Project showed that there is signifcant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental fnd‐ings create legal, ethical, and fnancial challenges for researchers. Current federal and international guidelines are not adequate. Plans for dealing with incidental fndings need to be established in the study design and reviewed and approved by the Institutional Review Board.
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ISSN:1073-1105
1748-720X
DOI:10.1111/j.1748-720X.2008.00272.x