Mucosa-associated lymphoid tissue lymphoma in labial minor salivary glands - case report and literature review

• Published in: Journal of Oral Diagnosis Vol. 4; pp. 1 - 5
• Main Authors: Oba, Marina Kimie, De-Macedo, Leandro Dorigan, Motta, Ana Carolina Fragoso, Ricz, Hilton Marcos Alves, De-Freitas, Luiz Carlos Conti, Saggioro, Fabiano Pinto, Innocentini, Lara Maria Alencar Ramos
• Format: Journal Article
• Language: English
• Published: 15.01.2019
• ISSN: 2525-5711; 2525-5711
• DOI: 10.5935/2525-5711.20190008

Mucosa-associated lymphatic tissue (MALT) lymphomas commonly occur in the stomach however, rare cases of MALT lymphomas involve the minor salivary gland. We did a literature review and described the fourth case in the English literature of adults affected by a MALT lymphoma in the lip. A 68-year-old woman with probable primary Sjögren’s syndrome (SS) was referred to our dentistry and stomatology service, complaining that her lower lip had progressively thickened during the past 4 years. An incisional biopsy was performed, and the microscopic examination showed a dense, diffuse lymphoplasmacytic infiltration of the salivary glands, with plasmacytic differentiation. The immunohisto- chemical analysis revealed diffuse positivity of the neoplastic cells for CD20 and BCL-2; the plasma cells were positive for CD138 and Lambda, which was consistent with MALT lymphoma. SS and Immunoglobulin G4-related disease were excluded. The total regression of the lesion was obtained after treatment with surgery, chemotherapy, and radiotherapy.