Literally Malignant Hypertension

Ectopic ACTH (adrenocorticotropic hormone) syndrome, EAS, is extremely rare, accounting for only 10–20% of all ACTH-dependent Cushing’s syndromes, and only 5–10% of all types of Cushing’s syndromes. Given the extremely aggressive behavior of malignancies, EAS is typically associated with significant...

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Bibliographic Details
Published inSN comprehensive clinical medicine Vol. 3; no. 9; pp. 1960 - 1964
Main Authors Seok, Kieun, Hallanger-Johnson, Julie, Holmstrom, Bjorn, Hembree, Timothy, Sharda, Esha, Ramsakal, Asha, Verma, Neha
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.09.2021
Subjects
Medicine
Medicine & Public Health
Topical Collection on Medicine
Ectopic adrenocorticotropic hormone syndrome
Neuroendocrine carcinoma
Cushing’s syndrome
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Summary:Ectopic ACTH (adrenocorticotropic hormone) syndrome, EAS, is extremely rare, accounting for only 10–20% of all ACTH-dependent Cushing’s syndromes, and only 5–10% of all types of Cushing’s syndromes. Given the extremely aggressive behavior of malignancies, EAS is typically associated with significantly higher levels of ACTH and cortisol, the difference being 100–1000-fold greater than in Cushing’s disease. Consequently, clinical symptoms and manifestations of EAS can be more severe and rapid in onset. In this case report, we describe the course of EAS-induced malignant hypertension in a 40-year-old patient who was subsequently diagnosed with high-grade poorly differentiated large cell neuroendocrine carcinoma (NEC).
ISSN:2523-8973
2523-8973
DOI:10.1007/s42399-021-00959-4