Reaction of Carbon Disulfide with Cyanoacetic Acid Hydrazide: Novel Synthesis of Thiazole and Thiazolo[4,5- c ]pyrazole

The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.

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Bibliographic Details
Published inJournal of chemical research Vol. 23; no. 1; pp. 10 - 11
Main Authors Mohareb, Rafat M., Aziz, Suzan I., Abdel-Sayed, Nadia I., El-Banna, Ahmed H.
Format Journal Article
LanguageEnglish
Published 01.01.1999
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Summary:The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.
ISSN:1747-5198
2047-6507
DOI:10.1177/174751989902300111