Reaction of Carbon Disulfide with Cyanoacetic Acid Hydrazide: Novel Synthesis of Thiazole and Thiazolo[4,5- c ]pyrazole
The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.
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Published in | Journal of chemical research Vol. 23; no. 1; pp. 10 - 11 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
01.01.1999
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Online Access | Get full text |
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Summary: | The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23. |
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ISSN: | 1747-5198 2047-6507 |
DOI: | 10.1177/174751989902300111 |