Hepatic reaction dose for parenchymal changes on G d‐ EOB ‐ DTPA ‐enhanced magnetic resonance images after stereotactic body radiation therapy for hepatocellular carcinoma
Abstract Introduction The present study evaluated the threshold dose for hepatic parenchymal changes on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid ( G d‐ EOB ‐ DTPA )‐enhanced magnetic resonance ( MR ) images after stereotactic body radiation therapy ( SBRT ) for hepatocellular carci...
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Published in | Journal of medical imaging and radiation oncology Vol. 60; no. 1; pp. 96 - 101 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.02.2016
|
Online Access | Get full text |
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Summary: | Abstract
Introduction
The present study evaluated the threshold dose for hepatic parenchymal changes on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (
G
d‐
EOB
‐
DTPA
)‐enhanced magnetic resonance (
MR
) images after stereotactic body radiation therapy (
SBRT
) for hepatocellular carcinoma (
HCC
).
Methods
Twenty patients with available data of follow‐up
MR
images acquired 2–4 months after completion of
SBRT
were selected among the registered patients.
SBRT
was performed using multiple coplanar and non‐coplanar beams with energies of 6 or 15 MV. All patients were treated with doses of 45 Gy administered in three fractions over 3 consecutive days. For image registration between planning computed tomography (
CT
) and
MR
images, landmark‐based rigid body registration was performed using
MIM
software.
Results
Seventeen patients were included in the analysis. The median discrepancies between planning
CT
and
MR
images in the left–right, anterior–posterior and superior–inferior directions were 1.38 mm, 1.24 mm and 1.72 mm, respectively. The median
D
50
value for the defect in the hepatobiliary phase of
G
d‐
EOB
‐
DTPA
‐enhanced
MR
images after
SBRT
was 19.8 Gy (range, 14.2–28.7 Gy), with
R
2
values ranging from 0.76 to 0.99.
Conclusions
The threshold dose for parenchymal changes in the hepatobiliary phase of
G
d‐
EOB
‐
DTPA
‐enhanced
MR
images performed 2–4 months after 45 Gy of
SBRT
in three fractions was approximately 20 Gy. Our results provide the basis for further research on the functional loss of liver parenchyma after
SBRT
. |
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ISSN: | 1754-9477 1754-9485 |
DOI: | 10.1111/1754-9485.12393 |