Exploring the antioxidant activity of 1-(piperidin-1-yl) propane-1,2-dione 4-phenylthiosemicarbazone and 3d metal coordination compounds with this ligand

• Published in: Studia Universitatis Moldaviae. Științe Reale şi ale naturii no. 1(171); pp. 239 - 246
• Main Authors: Graur, Ianina, Maxim, Mihail, Graur, Vasilii, Tsapkov, Victor, Gulea, Aurelian, Garbuz, Olga
• Format: Journal Article
• Language: English
• Published: 01.06.2024
• ISSN: 1814-3237; 1857-498X
• DOI: 10.59295/sum1(171)2024_28

The new 1-(piperidin-1-yl)propane-1,2-dione 4-phenylthiosemicarbazone (HL) and its 7 coordination compounds [Cu(L)X] (X = Br- (I); Cl- (II); NO3 - (III); CH3COO- (IV); Cl2CHCOO- (V)), [Co(L)2]NO3 (VI), [Fe(L)2]NO3 (VII) have been synthesized and characterized by elemental analysis, FTIR, 1H, 13C NMR spectra and molar electric conductibility. For the obtained compounds it was studied the antioxidant activity towards ABTS•+ radical cation. Uncoordinated 4-phenylthiosemicarbazone HL is the most active one with IC50 14.1 μM. Its activity is higher than that of Trolox which is used in medicine as an antioxidant. Among all the synthesized coordination compounds, the iron(III) complex VII showed the greatest activity. The antioxidant activity of metal complexes is influenced by the anion and the nature of the central metal atom.