Association of hs-CRP with Serum Creatinine Levels in Chronic Kidney Diseases

• Published in: Indian journal of clinical medicine
• Main Authors: Goriya, Shivani, Priya, Nivedita
• Format: Journal Article
• Language: English
• Published: 21.10.2024
• ISSN: 2633-9447; 1179-9161
• DOI: 10.1177/26339447241287048

Introduction Chronic kidney disease (CKD) is a prevalent condition characterized by a progressive decline in kidney function over time. It is associated with various complications, including cardiovascular disease and mortality. Inflammation, as indicated by elevated levels of high-sensitivity C-reactive protein (hs-CRP), has been implicated in the pathogenesis and progression of CKD. Serum creatinine (S. creatinine) levels, on the other hand, are commonly used as a marker to estimate kidney function. Aim The objective of this study was to examine the relationship between hs-CRP levels and S. creatinine levels in CKD patients. By investigating this association, this study aimed to shed light on the potential interplay between inflammation and kidney dysfunction in CKD. Methods We conducted a cross-sectional study in the Parul Sevashram Hospital, Vadodara. The study consisted of 80 CKD patients with 51 males and 29 females. The hs-CRP and creatinine levels were estimated for the study and further evaluated statistically for finding the association between them. Results The study observed a gender distribution with 63.75% male and 36.25% female patients. Among males, 41.17% had hs-CRP levels >2 mg/L, with a mean ± standard deviation (SD) creatinine value of 4.63 ± 0.32 mg/dL. In females, only 13.79% had hs-CRP levels >2 mg/L, with a mean ± SD creatinine value of 4.62 ± 0.30 mg/dL. The statistical analysis using Fisher’s exact test showed a highly significant association between hs-CRP and S. creatinine levels ( P < .01). Conclusion This study demonstrated a strong association between hs-CRP levels and S. creatinine levels in patients with CKD. As S. creatinine levels increased, there was a corresponding rise in hs-CRP levels. This suggests that monitoring hs-CRP levels could be valuable in assessing the progression of renal dysfunction and predicting cardiovascular complications in CKD patients. Further research is needed to fully comprehend the underlying mechanisms driving this association.