Synthesis and evaluation of 6-Fluoro benzothiazole substituted quinazolinones

• Published in: Current Trends in Pharmacy and Pharmaceutical Chemistry Vol. 4; no. 1; pp. 35 - 40
• Main Authors: Niharika, P., Risy Namratha, J, Sunitha, N., Manohar Babu, S.
• Format: Journal Article
• Language: English
• Published: 28.02.2022
• ISSN: 2582-5062; 2582-5062
• DOI: 10.18231/j.ctppc.2022.007

The present work was hypothesized to synthesize Benzothiazole substituted diethyl amino Quinazolinone derivatives and evaluate their antimicrobial activity. Quinazolinones were synthesized from condensation of 2-amino benzothiazole, anthranilic acid and acetic anhydride further followed by condensation with formaldehyde and diethyl amine. Antimicrobial activity was evaluated by agar disc diffusion using organisms and anti-inflammatory and antioxidant activies were studied using albumin denaturation and hydrogen peroxide radical scavenging methods. The structures of the synthesized Quinazolinone derivatives were confirmed by spectral analysis, such as IR, H-NMR and among the derivatives screened, the compounds 4d, 4f 4g, 4h have appreciable antimicrobial activity compared to standards. The compounds (4a-4h) have least anti-inflammatory activity while compound 4g have significant antioxidant activity as that of positive control.