Evaluation of Anticancer Activities of Clerodendrum formicarum Gurke (Lamiaceae) and Syzygium Cordatum Hochst ex Krauss (Myrtaceae) Harvested in the City of Lubumbashi and its Surroundings in the Democratic Republic Of The Congo

• Published in: Clinical Microbiology and Research pp. 1 - 5
• Main Authors: Mwene-Mbeja, Topwe Milongwe, Spino, Claude, Poirier, Donald, Mutombo, Emery Kalonda, Roy, Jenny, Mulowayi, Kanyinda, Kaseya, Kasongo, Kitambala, Marsi Mbayo, Gagnon, René
• Format: Journal Article
• Language: English
• Published: 29.06.2020
• ISSN: 2674-418X; 2674-418X
• DOI: 10.31487/j.CMR.2020.01.04

The main objective of this study was to extract the essential oils from Clerodendrum formicarum and Syzygium cordatum in order to determine the anticancer activity and establish the chemical constituents of that kind of essential oils. Hence, we have used hydrodistillation method to obtain the desired extracts or samples of essential oils. Indeed, the assessment of the anticancer activities showed that, at 100 µg/mL, the essential oils from S. cordatum inhibited the proliferation (98.2%) of breast cancer (MCF-7) cells. In the same context, the essential oils from C. formicarum also inhibited the proliferation (98.9%) of breast cancer (MCF-7) cells. We have additionally determined the chemical composition of the essential oils by GC-MS and identified 17 compounds in C. formicarum including caryophyllene (18.6%), (E)-3,7-dimethylocta1,3,6-triene (7.6%), β-Myrcene (6.2%), and [1S-(1α, 7α, 8α)]-1,8a-dimethyl-7-(1-methylethenyl)- 1,2,3,5,6,7,8,8a-octahydronaphthalene (5.6%) as major compounds. We have observed an unknown compound (25%) in the essential oils from C. formicarum (H-12) The chemical analysis showed 28 compounds in S. cordatum (HE-9) essential oils such as caryophyllene (7.2%) and cedrene (6.7%) as major compounds