In vitro-Amplifikation humaner hämatopoetischer Stammzellen im 3D-System

Abstract A promising strategy to increase the numbers of hematopoietic stem cells (HSCs) for clinical applications, like stem cell transplantation, is offered by advanced in vitro culture systems. We developed artificial 3D bone marrow-like scaffolds made of polydimethylsiloxane (PDMS) mimicking the...

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Bibliographic Details
Published inBiospektrum Vol. 28; no. 5; pp. 489 - 492
Main Authors Marx-Blümel, Lisa, Marx, Christian, Schober, Andreas, Beck, James F.
Format Journal Article
LanguageGerman
Published 01.09.2022
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Summary:Abstract A promising strategy to increase the numbers of hematopoietic stem cells (HSCs) for clinical applications, like stem cell transplantation, is offered by advanced in vitro culture systems. We developed artificial 3D bone marrow-like scaffolds made of polydimethylsiloxane (PDMS) mimicking the natural HSC niche in vitro . These 3D PDMS scaffolds in combination with an optimized culture medium allow the amplification of high numbers of undifferentiated HSCs by activating specific molecular signaling pathways.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-022-1798-2