TaCl 5 ‐Catalyzed Amidation of Carboxylic Acids with Amines

Abstract The reaction of alkyl‐ and aryl‐substituted carboxylic acids with primary and secondary amines under the action of 0.2 equiv. TaCl 5 leads to selective formation of carboxylic acid amides of various structures. TaCl 5 ‐catalyzed formation of amides was demonstrated to proceed equally select...

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Published inChemistrySelect (Weinheim) Vol. 8; no. 7
Main Authors Gabdullin, Azat M., Kadikova, Rita N., Mozgovoj, Oleg S., Ramazanov, Ilfir R.
Format Journal Article
LanguageEnglish
Published 16.02.2023
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Summary:Abstract The reaction of alkyl‐ and aryl‐substituted carboxylic acids with primary and secondary amines under the action of 0.2 equiv. TaCl 5 leads to selective formation of carboxylic acid amides of various structures. TaCl 5 ‐catalyzed formation of amides was demonstrated to proceed equally selectively both in toluene and methylene chloride, hexane, diethyl ether and 1,4‐dioxane solutions.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202204298