Synthesis of 1,2‐Diaryl‐1 H ‐indol‐4‐ols and 1,2‐Diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones from Arylglyoxals and Enamines through Domino Reactions

A series of 1,2‐diaryl‐ and 1‐alkyl‐2‐aryl‐1 H ‐indol‐4‐ols and 1,2‐diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones have been prepared by the domino reactions of arylglyoxals and enamines at reflux in non‐nucleophilic and nucleophilic solvents such as acetonitrile and ethanol, respectively. The trans...

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Published inEuropean journal of organic chemistry Vol. 2013; no. 12; pp. 2479 - 2485
Main Authors Maity, Subhendu, Pathak, Sudipta, Pramanik, Animesh
Format Journal Article
LanguageEnglish
Published 01.04.2013
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Summary:A series of 1,2‐diaryl‐ and 1‐alkyl‐2‐aryl‐1 H ‐indol‐4‐ols and 1,2‐diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones have been prepared by the domino reactions of arylglyoxals and enamines at reflux in non‐nucleophilic and nucleophilic solvents such as acetonitrile and ethanol, respectively. The transformation occurs by annulation followed by aromatization without the use of any metal or catalyst.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201201616