An adapted purification procedure to improve the quality of 90 Y for clinical use
Abstract There is an increasing interest for 90 Y for radionuclide therapy. However, radioimmunotherapy, one of the most important applications for 90 Y, demands a very high purity product. Obtaining a high quality 90 Y is difficult not only because of the complex and time consuming production schem...
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Published in | Radiochimica acta Vol. 97; no. 12; pp. 739 - 746 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.12.2009
|
Online Access | Get full text |
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Summary: | Abstract
There is an increasing interest for
90
Y for radionuclide therapy. However, radioimmunotherapy, one of the most important applications for
90
Y, demands a very high purity product. Obtaining a high quality
90
Y is difficult not only because of the complex and time consuming production schemes but also because of the quality control which has challenging tasks like the determination of
90
Sr at very low concentrations. The present paper investigates a reported purification procedure for the removal of stable metal trace contaminants from an
90
Y solution, seeking for its potential use in the elimination of the radioactive contaminant
90
Sr and its fast determination. For this purpose a washing step with HNO
3
acid is introduced to elute
90
Sr, the order of each acid solution is rearranged to reduce the potential contaminants present in acids and the size of the column is reduced to further optimize the procedure. As a result, an improved purification method is obtained, which allows the removal of both trace metal contaminants and
90
Sr from an
90
Y solution and the measurement of
90
Sr/
90
Y ratios of the order of 10
-7
, which are well below the established pharmacopeia limit of 2×10
-5
. |
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ISSN: | 0033-8230 2193-3405 |
DOI: | 10.1524/ract.2009.1666 |