New susceptibility locus for coronary artery disease on chromosome 3q22.3

• Published in: Nature genetics Vol. 41; no. 3; pp. 280 - 282
• Main Authors: Erdmann, Jeanette, Großhennig, Anika, Braund, Peter S, König, Inke R, Hengstenberg, Christian, Hall, Alistair S, Linsel-Nitschke, Patrick, Kathiresan, Sekar, Wright, Ben, Trégouët, David-Alexandre, Cambien, Francois, Bruse, Petra, Aherrahrou, Zouhair, Wagner, Arnika K, Stark, Klaus, Schwartz, Stephen M, Salomaa, Veikko, Elosua, Roberto, Melander, Olle, Voight, Benjamin F, O'Donnell, Christopher J, Peltonen, Leena, Siscovick, David S, Altshuler, David, Merlini, Piera Angelica, Peyvandi, Flora, Bernardinelli, Luisa, Ardissino, Diego, Schillert, Arne, Blankenberg, Stefan, Zeller, Tanja, Wild, Philipp, Schwarz, Daniel F, Tiret, Laurence, Perret, Claire, Schreiber, Stefan, Mokhtari, Nour Eddine El, Schäfer, Arne, März, Winfried, Renner, Wilfried, Bugert, Peter, Klüter, Harald, Schrezenmeir, Jürgen, Rubin, Diana, Ball, Stephen G, Balmforth, Anthony J, Wichmann, H-Erich, Meitinger, Thomas, Fischer, Marcus, Meisinger, Christa, Baumert, Jens, Peters, Annette, Ouwehand, Willem H, Deloukas, Panos, Thompson, John R, Ziegler, Andreas, Samani, Nilesh J, Schunkert, Heribert
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2009; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Binding sites; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; brief-communication; Cancer Research; Cardiac and Cardiovascular Systems; Cardiology and Cardiovascular Disease; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular system; Case-Control Studies; Charitable foundations; Chromosomes; Chromosomes, Human, Pair 3; Clinical Medicine; Coronary Artery Disease - genetics; Coronary heart disease; Data base management; Disease susceptibility; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Germany; Heart; Hepatocyte Nuclear Factor 1-alpha - genetics; Human Genetics; Humans; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Myocardial infarction; Polymorphism, Single Nucleotide; Quality control; Quantitative Trait Loci; ras Proteins - genetics; Risk factors; Single nucleotide polymorphisms; Studies; Thrombosis; Vein & artery diseases; Germany; Cardiovascular disease; Chromosome; Sensitivity; Coronary heart disease; Susceptibility locus
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.307

Jeanette Erdmann and colleagues identify a locus on chromosome 3q22.3 associated with coronary artery disease. The SNP with the strongest association is in MRAS , which encodes a membrane-anchored GTP-binding protein. We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS ( P = 7.44 × 10 −13 ; OR = 1.15, 95% CI = 1.11–1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 ( P = 4.81 × 10 −7 ; OR = 1.08, 95% CI = 1.05–1.11).