KAl(SO 4 ) 2 ·12H 2 O (Alum) Catalyzed One‐Pot Three‐Component Synthesis of 2‐Alkyl and 2‐Aryl‐4(3 H )‐quinazolinone under Microwave Irradiation and Solvent Free Conditions
Abstract Twenty 2,3‐disubstituted‐4(3 H )‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO 4 ) 2 ·12H 2 O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐ p ‐to...
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| Published in | Chinese journal of chemistry Vol. 29; no. 9; pp. 1982 - 1984 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
01.09.2011
|
| Online Access | Get full text |
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| Summary: | Abstract
Twenty 2,3‐disubstituted‐4(3
H
)‐quinazolinones were synthesed by one‐pot three‐component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO
4
)
2
·12H
2
O (Alum) under microwave irradiation and solvent‐free conditions. 6‐Bromo‐2‐propyl‐3‐
p
‐tolylquinazolin‐4(3
H
)‐one (
4m
), 6‐bromo‐2‐methyl‐3‐phenethylquinazolin‐4(3
H
)‐one (
4n
) and 6‐bromo‐2‐ethyl‐3‐phenethylquinazolin‐4(3
H
)‐one (
4o
) were characterized by IR,
1
H NMR,
13
C NMR and elemental analysis. |
|---|---|
| ISSN: | 1001-604X 1614-7065 |
| DOI: | 10.1002/cjoc.201180344 |