Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and A po B in patients undergoing primary prevention of cardiovascular disease: A triple‐blind, 6‐month follow‐up, placebo‐controlled, randomized trial

• Published in: Molecular nutrition & food research Vol. 56; no. 5; pp. 810 - 821
• Main Authors: Tomé‐Carneiro, Joao, Gonzálvez, Manuel, Larrosa, Mar, García‐Almagro, Francisco J., Avilés‐Plaza, Francisco, Parra, Soledad, Yáñez‐Gascón, María J., Ruiz‐Ros, José A., García‐Conesa, María T., Tomás‐Barberán, Francisco A., Espín, Juan Carlos
• Format: Journal Article
• Language: English
• Published: 01.05.2012
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201100673

Scope The cardioprotective role of resveratrol as part of the human diet is not yet clear. Our aim was to investigate the effect of a grape supplement containing 8 mg resveratrol in oxidized LDL ( LDL ox), apolipoprotein‐ B ( A po B ), and serum lipids on statin‐treated patients in primary cardiovascular disease prevention ( PCP ). Methods and results A triple‐blind, randomized, placebo‐controlled trial was conducted. Seventy‐five patients (three parallel arms) consumed one capsule (350 mg) daily for 6 months containing resveratrol‐enriched grape extract ( GE ‐ RES , S tilvid®), grape extract ( GE , similar polyphenolic content but no resveratrol), or placebo (maltodextrin). After 6 months, no changes were observed in the placebo group and only LDL cholesterol ( LDL c) decreased by 2.9% ( p = 0.013) in the GE group. In contrast, LDL c (−4.5%, p = 0.04), A po B (−9.8%, p = 0.014), LDL ox (−20%, p = 0.001), and LDL ox/ A po B (−12.5%, p = 0.000) decreased in the S tilvid® group, whereas the ratio non‐ HDL c (total atherogenic cholesterol load)/ A po B increased (8.5%, p = 0.046). No changes were observed in hepatic, thyroid, and renal function. No adverse effects were observed in any of the patients. Conclusion This GE ‐ RES reduced atherogenic markers and might exert additional cardioprotection beyond the gold‐standard medication in patients from PCP . The presence of resveratrol in the GE was necessary to achieve these effects.