Metal‐Ion‐Binding Analogs of Ribonucleosides: Preparation and Formation of Ternary Pd 2+ and Hg 2+ Complexes with Natural Pyrimidine Nucleosides
Abstract Four metal‐ion‐binding nucleosides, viz. 2,6‐bis(1‐methylhydrazinyl)‐9‐( β ‐ D ‐ribofuranosyl)‐9 H ‐purine ( 2a ) and its N ‐acetylated derivative, 2b , 2,4‐bis(3,5‐dimethyl ‐ 1 H ‐pyrazol‐1‐yl)‐5‐( β ‐ D ‐ribofuranosyl)pyrimidine ( 3 ), and 2,4‐bis(1‐methylhydrazinyl)‐5‐( β ‐ D ‐ribofurano...
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| Published in | Helvetica chimica acta Vol. 96; no. 9; pp. 1658 - 1669 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.09.2013
|
| Online Access | Get full text |
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| Summary: | Abstract
Four metal‐ion‐binding nucleosides,
viz.
2,6‐bis(1‐methylhydrazinyl)‐9‐(
β
‐
D
‐ribofuranosyl)‐9
H
‐purine (
2a
) and its
N
‐acetylated derivative,
2b
, 2,4‐bis(3,5‐dimethyl
‐
1
H
‐pyrazol‐1‐yl)‐5‐(
β
‐
D
‐ribofuranosyl)pyrimidine (
3
), and 2,4‐bis(1‐methylhydrazinyl)‐5‐(
β
‐
D
‐ribofuranosyl)pyrimidine (
4
) have been synthesized. The ability of these nucleosides and the previously prepared 2,6‐bis(3,5‐dimethyl
‐
1
H
‐pyrazol‐1‐yl)‐9‐(
β
‐
D
‐ribofuranosyl)‐9
H
‐purine to form Pd
2+
‐ and Hg
2+
‐mediated complexes with uridine has been studied by
1
H‐NMR spectroscopy. To obtain additional support for the interpretation of the NMR data, comparative measurements on the ternary‐complex formation between pyridine‐2,6‐dicarboxamide (
5
), pyrimidine nucleosides, and K
2
PdCl
4
were carried out. |
|---|---|
| ISSN: | 0018-019X 1522-2675 |
| DOI: | 10.1002/hlca.201300042 |