99 Mo/ 99m Tc radioisotope generator based on adsorption of 99 Mo (VI) on cerium (IV) molybdate column matrix

• Published in: Radiochimica acta Vol. 106; no. 12; pp. 991 - 999
• Main Authors: El-Said, Hassan, Ramadan, Hala, Abbas, Mahmoud, El-Hashash, Maher
• Format: Journal Article
• Language: English
• Published: 01.12.2018
• ISSN: 0033-8230; 2193-3405
• DOI: 10.1515/ract-2018-0002

Abstract Based on neutron activated 99 Mo, a procedure for preparation of 99 Mo/ 99m Tc radioisotope generator was developed. Batch equilibration method was used to investigate the sorption behavior of Mo (VI) (10 −4 M) in chloride and nitrate solutions on cerium (IV) molybdate gel matrix using 99 Mo radiotracer. The breakthrough sorption capacity of cerium molybdate gel matrix for 99 Mo (VI) (3×10 −2 M) were found to be 0.54 mmol/g of the sorbent [1 g column (0.6 cm i.d.)]. Elution performance of the generated 99m Tc from cerium molybdate- 99 Mo chromatographic column was investigated as a function of inside diameter of the column, amount of the bed matrix and flow rate of the eluent. Based on the obtained results, 99 Mo/ 99m Tc radioisotope generator was prepared based on adsorption of neutron activated 99 Mo (VI) of low specific activity onto chromatographic columns packed with 5 g cerium molybdate gel matrix. The radioactivity of 99m Tc is periodically eluted with 10 mL 0.9% NaCl solution at a flow rate of 1 mL/min. Elution yield of 78±5% was obtained with high chemical, radionuclidic ( 99 Mo breakthrough 1×10 −3 ±0.3×10 −3 %) and radiochemical purity (97±2%).