5-Hydroxy-3-vinyl-2(5H)-furanone -a New Inhibitor of Human Synovial Phospholipase A 2 and Platelet Aggregation from Fermentations of a Calyptella Species (Basidiomycetes)

Abstract 5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A 2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete...

Full description

Saved in:
Bibliographic Details
Published inZeitschrift für Naturforschung C. A journal of biosciences Vol. 50; no. 5-6; pp. 403 - 409
Main Authors Lorenzen, Kirsten, Anke, Timm, Konetschny-Rapp, Silvia, Scheuer, Werner
Format Journal Article
LanguageEnglish
Published 01.06.1995
Online AccessGet full text

Cover

More Information
Summary:Abstract 5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A 2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities.
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-1995-5-611